In 2014, NIAID published Antibacterial Resistance Program: Current Status and Future Directions, a research framework that described NIAID’s approach to combat AR through basic, translational and clinical research and laid out areas for intensified research to combat AR. Key elements of this framework were amplified in the USG’s National Action Plan for Combating Antibiotic-Resistant Bacteria. The strategic approaches outlined in the 2014 framework are listed below; each has been followed by workshops, targeted funding opportunities, or both:
- Systems Biology and Antibacterial Resistance: New Directions for Drug Discovery—Using a holistic approach to examine molecular networks of host-pathogen interactions and global changes in response to drug exposure.
- Harnessing the Immune System to Combat Bacterial Infections—Enhancing host immune response through immunological interventions and immunotherapeutics.
- Disarm, But Leave Unharmed: Exploring Anti-Virulence Strategies—Targeting bacterial virulence factors without directly killing bacteria is less likely to induce selective pressure.
- Synthetic Microbiota: An Ecobiological Approach—Designing microbial communities as biologic products to mitigate infectious diseases and their sequelae.
- Less is Better: Diagnostics to Guide Use of Narrow-Spectrum Therapeutics—Decreasing selective pressure by enabling the use of therapeutics targeted to a pathogen or group of pathogens.
- Exploiting Natural Predators: The Specificity of Phage Therapy—Using phage or phage-derived lysins to kill specific bacteria while preserving microbiota.
- Teaching Old Drugs New Tricks: Extending the Clinical Utility of Antibacterial Drugs— Optimizing use of existing drugs and combination therapies to suppress emergence of resistance and minimize toxicity.
Now, NIAID is is seeking public input into strategic approaches that should be emphasized over the next five years. NIAID is specifically seeking input into the following:
- Input on additional research activities needed to help advance the above-listed strategic approaches.
- Input on additional strategic approaches or technologies that have the potential to transform our understanding of and ability to prevent, diagnose and/or treat resistant bacterial infections that should be further investigated.
All comments must be submitted electronically to the following mailbox: NIAIDAntibioticResistanceRFI2019@. niaid.nih.gov
Responses (no longer than 500 words in MS Word or pdf format) must be received by 11:59:59 pm (ET) on March 8th, 2019.
More information: https://grants.nih.gov/grants/guide/notice-files/NOT-AI-19-033.html