Basilea supported by CARB-X funding

Basilea supported by CARB-X funding

  • 19/05/2021

CARB-X is awarding Swiss listed company Basilea Pharmaceutica International up to US $2.7m to develop a novel class of antibiotics to treat Gram-negative bacterial infections. 

The project aims to develop selective small-molecule inhibitors of 1-deoxy-D-xylulose 5-phosphate reductor isomerase (DXR), an enzyme in the bacterial isoprenoid biosynthesis pathway that is essential for the survival of many drug-resistant pathogens, including carbapenem-resistant Enterobacterales (CRE), Acinetobacter baumannii and multidrug-resistant (MDR) Pseudomonas aeruginosa.

“The Basilea project is in the early stages of development, with a novel chemical class working with a novel mechanism of inhibition of bacterial growth. Together, these offer a potential advantage where the development of resistance is concerned and – as such – offer great promise for a new therapy to treat serious hospital infections,” says Erin Duffy, R&D Chief of CARB-X.

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